Sarolaner/Moxidectin/Pyrantel
“This page provides important general information for pet owners whose animals have been prescribed Sarolaner/Moxidectin/Pyrantel during a consultation by Dr Noor in Perth.”
Key Information
Note: This handout is meant to address questions people often ask. It does not include every detail that exists about this medicine. It does not replace guidance from your veterinary care team. Sarolaner/Moxidectin/Pyrantel information for pets in Perth.
- This medicine is used in dogs to kill and help stop fleas and ticks, to treat and manage certain intestinal worms, and to help stop heartworm disease.
- For it to work as intended, it needs to be given once each month.
- Do not give this product to cats.
- If your dog develops shaking, seizures, or trouble walking after getting this medicine, contact your veterinarian right away.
Description
This product combines three parasite-fighting medicines:
- Moxidectin: used to help prevent heartworm disease and to help control infections from intestinal worms.
- Pyrantel: used to treat and help control infections from intestinal worms.
- Sarolaner: used to prevent and treat flea and tick problems.
It comes as a chewable tablet.
Other common names
Simparica TRIO
Uses
- For dogs:
- treatment and prevention of fleas, ticks, and intestinal worms (roundworms and hookworms)
- prevention of heartworm disease
Before this medication is given
No medicine is completely safe for every patient. Talk with your veterinarian about:
- Any other medicines or supplements your dog is currently receiving
- Any health problems your dog has now, or has had before
- Any unwanted reactions your dog has had to medicines in the past
- The possible risks of using this medicine if your dog is pregnant or nursing
Before starting heartworm prevention medicines, dogs should have a heartworm test result that is negative.
Warnings for animals
Do not use this medicine in:
- Cats
- Dogs that have an allergy to any ingredient in this product
- Dogs younger than 8 weeks of age or weighing under 2.8 pounds
Use extra care in:
- Dogs that have seizure conditions, have had seizures before, or have other brain or nerve system problems
Some animal competitions do not allow certain medicines. If your animal is competing, check the rules while your animal is taking this medicine.
While using this medicine, a heartworm test once a year is recommended.
At the recommended dose, this medicine can be used safely in dogs that have the MDR1 genetic mutation.
Warnings for humans
After you handle any medicine, wash your hands.
How do I give this medication?
- To work properly, give this medicine once every month.
- You may give it with food or without food.
- It works best when the tablet is chewed before it is swallowed. If your dog usually swallows treats whole, you may split the tablet into smaller pieces before offering it.
- Confirm your dog eats the full dose. Watch closely so you can see that none of it is spit out.
- If your dog does not finish the full dose, another dose may be needed. Contact your veterinary clinic for instructions if this happens.
- For flea control to work well, every animal in the home must be on a suitable flea prevention product.
Give this medicine exactly the way your veterinarian ordered it. Always follow the directions printed on the prescription label.
Side effects
Common — contact your veterinarian if these problems are strong, keep happening, or get worse over time:
- Vomiting, loose stool/diarrhea, or reduced appetite
- Low energy
Severe — stop giving the medicine and contact your veterinarian immediately if you see any of the following:
- Shaking (tremors) or seizures
- Trouble walking, weakness, or stumbling
How will I know it’s working with Sarolaner/Moxidectin/Pyrantel?
- If your dog is taking this as prevention, you may not notice any visible change. Your veterinarian will check how well it is working by doing routine heartworm and parasite testing.
- If your dog is taking this to treat an active flea/tick problem or an intestinal worm infection, your dog’s symptoms should begin to improve as the parasites die.
- Fleas should start dying within 4 to 8 hours.
- Ticks and intestinal worms may take 12 hours or more to die.
If your dog’s symptoms get worse or do not get better, contact your veterinary clinic.
How long will the medication effects last?
When given monthly, this medicine protects for the full month.
How long do I give it for?
To provide the best protection, this medicine should be given continuously.
Overdose
Possible signs of too much medicine include poor coordination, muscle twitching, or seizures.
If you see an overdose happen, or you think one may have happened, call your veterinarian or a pet poison control service (a consultation fee applies):
If you can, have the product or its label with you.
Missed dose
If you forget a dose:
- Give it as soon as you remember, and then go back to giving it monthly.
- If more than 6 weeks have passed since the previous dose, contact your veterinarian. Your dog may need a heartworm test earlier than normal.
If you are not sure what to do, call your veterinary clinic. Do not give an extra dose or two doses close together.
Storage
- Leave the tablet in the original blister packaging until you are ready to give it.
- Keep at room temperature.
- Keep away from light.
- Store where children and animals cannot reach it.
- These tablets are flavored like liver to encourage dogs to eat them. Because of this, it is important to store them securely and well out of reach to help prevent accidental overdose.
Disposal
Do not put this medicine into the toilet or pour it into a sink drain. Ways to get rid of unused or expired medicine include:
- Drug take-back sites:
- This is the best option when available. To locate a nearby site, contact local law enforcement or your waste management office.
- Home disposal:
- Place it in the household trash.
Do not keep leftover medicine for later use and do not give it to anyone else.
Questions?
Speak with your veterinarian.
“Disclaimer: The information on this page is provided as general educational material only. Every animal’s health situation is unique, and treatment decisions must be based on a full veterinary assessment. Always follow the specific instructions given during your consultation, and contact the prescribing veterinarian if you have any concerns.”